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The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Gene Name: | bleomycin hydrolase |
Family/Subfamily: | Protease , Cysteine C1 |
Synonyms: | BLMH, BH, BLM hydrolase, Bleomycin hydrolase, BMH |
Target Sequences: | NM_000386 NP_000377.1 Q13867 |
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