Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Gene Name: | chromobox homolog 4 |
Synonyms: | CBX4, Chromobox homolog 4, Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, NBP16, NS5ATP1-binding protein 16, HPC2, Polycomb 2 homolog, PC2, Pc class 2 homolog |
Target Sequences: | NM_003655 NP_003646.2 O00257 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.