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BIK shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
Gene Name: | BCL2-interacting killer (apoptosis-inducing) |
Synonyms: | BIK, Apoptosis inducer NBK, Bcl-2-interacting killer, BP4, Apoptosis-inducing NBK, BIP1, NBK |
Target Sequences: | NM_001197 NP_001188.1 Q13323 |
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