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DVL3 is a member of multigene family that also contains DVL1 and DVL2. The vertebrate dishevelled proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL3 encodes a predicted 716-amino acid polypeptide that shows 74% nucleotide similarity with human DVL1. Similarity is particularly high in the N-terminal region and there is more divergence in the C-terminal regions. Charcot-Marie-Tooth type 2B maps to chromosome 3q. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
Gene Name: | dishevelled segment polarity protein 3 |
Synonyms: | DVL3, DSH homolog 3, Dishevelled-3, KIAA0208 |
Target Sequences: | NM_004423 NP_004414.3 Q92997 |
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