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Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Gene Name: | mitogen-activated protein kinase kinase 7 |
Family/Subfamily: | Protein Kinase , MAP2K |
Synonyms: | MAP2K7, JNK kinase 2, MAP kinase kinase 7, MEK 7, Jnkk2, PRKMK7, SAPKK-4, SKK4, MAPK/ERK kinase 7, MAPKK 7, MAPKK7, SAPK kinase 4, JNK-activating kinase 2, JNKK 2, Map kinase kinase 7 beta 1, Map kinase kinase 7 gamma 2, MEK7, MKK7, SAPKK4 |
Target Sequences: | AF013589 AAC16273.1 O14733 |
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