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E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Gene Name: | mahogunin ring finger 1, E3 ubiquitin protein ligase |
Synonyms: | MGRN1, KIAA0544, Mahogunin, ring finger 1, RNF156, RING finger protein 156 |
Target Sequences: | AB011116 BAA25470.1 O60291 |
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