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BCL7A is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | B-cell CLL/lymphoma 7A |
Family/Subfamily: | Cancer |
Synonyms: | BCL7A, B-cell CLL/lymphoma 7A, BCL7, B-cell CLL/lymphoma-7 |
Target Sequences: | NM_020993 NP_066273.1 Q4VC05 |
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