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Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
Gene Name: | tousled-like kinase 2 |
Family/Subfamily: | Protein Kinase , TLK |
Synonyms: | TLK2, HsHPK, PKU-ALPHA, Tousled-like kinase 2, Serine/threonine kinase |
Target Sequences: | NM_006852 NP_006843.2 Q86UE8 |
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