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Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Gene Name: | mitogen-activated protein kinase kinase kinase 13 |
Family/Subfamily: | Protein Kinase , MLK(MAP3K) |
Synonyms: | MAP3K13, Leucine zipper-bearing kinase, LZK, Mixed lineage kinase, MLK, MEKK13 |
Target Sequences: | NM_004721 NP_004712.1 O43283 |
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