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Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Gene Name: | vav 2 guanine nucleotide exchange factor |
Synonyms: | VAV2, Vav 2 oncogene, VAV-2 |
Target Sequences: | NM_003371 NP_003362.2 P52735 |
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