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Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Gene Name: | centrosomal protein 164kDa |
Synonyms: | CEP164, Centrosomal protein of 164 kDa, Centrosomal protein 164kDa, KIAA1052, NPHP15 |
Target Sequences: | AB028975 BAA83004.2 Q9UPV0 |
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