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SLPI is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity.
Gene Name: | secretory leukocyte peptidase inhibitor |
Synonyms: | SLPI, ALK1, ALP, Antileukoprotease, BLPI, HUSI, Mucus proteinase inhibitor, HUSI-I, SLP1, Antileukoproteinase, Seminal proteinase inhibitor, WFDC4, HUSI-1, Protease inhibitor WAP4, WAP4 |
Target Sequences: | NM_003064 NP_003055.1 P03973 |
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