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CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Gene Name: | CD4 molecule |
Synonyms: | CD4, CD4 antigen, CD4 receptor, CD4mut, CD4 antigen (p55), CD4 molecule |
Target Sequences: | NM_000616 NP_000607.1 P01730 |
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