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CD3G is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency.
Gene Name: | CD3g molecule, gamma (CD3-TCR complex) |
Synonyms: | CD3G, CD3-GAMMA, CD3g antigen, T-cell receptor gamma chain, T-cell receptors gamma chain, T3G, T-cell receptor T3 gamma chain |
Target Sequences: | NM_000073 NP_000064.1 P09693 |
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