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Calcineurin A alpha (PPP3CA), a PP2B type serine/threonine phosphatase, is a catalytic subunit of calcineurin which acts as a calcium-dependent and calmodulin-stimulated modifier of phosphorylation status. PPP3CA has been shown to function in calcium signaling and is believed to function in the calmodulin activation of calcineurin, motor neuron disease and neuronal reorganization after ischemic injury. Based on studies in knockout mice, PPP3CA has been implicated in learning and memmory via hippocampal cytoskeletal changes.
Gene Name: | protein phosphatase 3, catalytic subunit, alpha isozyme |
Family/Subfamily: | Protein Phosphatase , PP2B |
Synonyms: | PPP3CA, Calcineurin A, CALN, CALNA, CALNA1, CNA1, PPP2B, Calcineurin A alpha, CAM-PRP catalytic subunit, CCN1, CNA, CNA alpha, pp2b-alpha |
Target Sequences: | NM_000944 NP_000935.1 Q08209 |
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