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This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
Gene Name: | methionine adenosyltransferase I, alpha |
Synonyms: | MAT1A, AdoMet synthase 1, AdoMet synthetase 1, MAT 1, MAT-I/III, MATA1, AMS1, MAT, SAMS1, SAMS |
Target Sequences: | NM_000429 NP_000420.1 Q00266 |
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