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Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.
Gene Name: | reticulocalbin 1, EF-hand calcium binding domain |
Synonyms: | RCN1, Proliferation-inducing gene 20, Reticulocalbin 1, Reticulocalbin-1, RCN, PIG20, RCAL, Reticulocalbin |
Target Sequences: | NM_002901 NP_002892.1 Q15293 |
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