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Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Gene Name: | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase |
Synonyms: | TRMU, MTO2 homolog, TRMT, MTO2, MTU1 |
Target Sequences: | NM_018006 NP_060476.2 O75648 |
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