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Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
Gene Name: | SMEK homolog 1, suppressor of mek1 (Dictyostelium) |
Synonyms: | SMEK1, FLFL1, KIAA2010, MSTP033, SMEK homolog 1, Smk1, PP4R3A, PPP4R3A, Smk-1 |
Target Sequences: | NM_032560 AAG39284.1 |
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