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Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Gene Name: | CDC-like kinase 1 |
Family/Subfamily: | Protein Kinase , LAMMER/Clk |
Synonyms: | CLK1, CDC-like kinase 1, CDC28/CDC2-like kinase, CLK, Protein kinase clk1, Protein tyrosine kinase STY, STY, Protein Kinase CLK |
Target Sequences: | NM_004071 NP_004062.2 P49759 |
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