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Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
Gene Name: | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
Synonyms: | ANP32A, Hepatopoietin Cn, I1PP2A, LANP, HPPCn, PHAP1, PHAPI, MAPM, PP32, C15orf1, Mapmodulin |
Target Sequences: | NM_006305 NP_006296.1 P39687 |
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