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ST8SIA4 catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
Synonyms: | ST8SIA4, Alpha-2,8-sialyltransferase 8D, PST, Sialyltransferase 8D, SIAT8D, ST8SiaIV, Polysialyltransferase-1, SIAT8-D, Sialytransferase St8Sia IV, ST8SIA-IV |
Target Sequences: | NM_005668 NP_005659.1 Q92187 |
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