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DHRS9 is a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants.
Gene Name: | dehydrogenase/reductase (SDR family) member 9 |
Synonyms: | DHRS9, 3-alpha-HSD, 3ALPHA-HSD, RDH-E2, RDHL, RDH15, Retinol dehydrogenase homolog, RDH-TBE, RETSDR8, SDR9C4 |
Target Sequences: | AF240697 NP_005762.2 Q9BPW9 |
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