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ADH4 encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
Gene Name: | alcohol dehydrogenase 4 (class II), pi polypeptide |
Synonyms: | ADH4, Alcohol dehydrogenase 4, Aldehyde reductase, ADH-2 |
Target Sequences: | NM_000670 NP_000661.2 P08319 |
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