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Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
Gene Name: | melanoma antigen family A, 2 |
Synonyms: | MAGEA2, Cancer/testis antigen 1.2, MAGE-2 antigen, MAGEA2A, Melanoma antigen 2, Melanoma antigen family A, 2, MAGE2, CT1.2, Melanoma-associated antigen 2 |
Target Sequences: | NM_005361 NP_005352.1 P43356 |
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