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CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
| Gene Name: | calcium/calmodulin-dependent protein kinase kinase 2, beta |
| Family/Subfamily: | Protein Kinase , CAMKK |
| Synonyms: | CAMKK2, CaM-kinase kinase 2, CaMKK beta, CAMKKB, CaM-KK beta, CaMKK, CAMKK beta protein, CaMKK 2, CaMKKbeta, KIAA0787, CaM KKB, CaM-kinase kinase beta, CaM-KK 2 |
| Target Sequences: | NM_006549 NP_006540.3 Q96RR4 |
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