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Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
Gene Name: | UBX domain protein 1 |
Synonyms: | UBXN1, 2B28, SAPK substrate protein 1, UBXD10, UBX domain protein 1, LOC51035, SAKS1, UBA/UBX 33.3 kDa protein |
Target Sequences: | NM_015853 NP_056937.2 Q04323 |
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