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NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
Gene Name: | N-myc (and STAT) interactor |
Synonyms: | NMI, Hou, N-myc and STAT interactor, N-myc-interactor, N-myc (and STAT) interactor, N-myc interactor |
Target Sequences: | NM_004688 NP_004679.2 Q13287 |
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