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Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.
Gene Name: | hematopoietically expressed homeobox |
Synonyms: | HHEX, HEX, HMPH, Homeobox protein HEX, HOX11L-PEN, PRHX, Homeobox protein PRH, PRH |
Target Sequences: | AF132550 AAF04349.1 P43120 |
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