Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
OTX2 is a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.
Gene Name: | orthodenticle homeobox 2 |
Synonyms: | OTX2, CPHD6, Homeobox protein OTX2, MCOPS5, Orthodenticle homeobox 2, Orthodenticle homolog 2 |
Target Sequences: | NM_021728 NP_068374.1 P32243 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.