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Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.
Gene Name: | distal-less homeobox 2 |
Synonyms: | DLX2, Distal-less homeo box 2, Distal-less homeobox 2, TES1, Homeobox protein DLX-2, TES-1 |
Target Sequences: | NM_004405 NP_004396.1 Q07687 |
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