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The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway.
Gene Name: | histamine receptor H2 |
Family/Subfamily: | GPCR , Histamine |
Synonyms: | HRH2, Gastric receptor I, H2R, Histamine 2 receptor, Gastric receptor 1, H2 histamine receptor, HH2R, Histamine type 2 receptor, Histamine H2 receptor, Histamine receptor H2 |
Target Sequences: | NM_022304 NP_071640.1 P25021 |
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