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Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Gene Name: | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
Synonyms: | SERPIND1, D22S673, HCII, HLS2, HC-II, HC2, Leuserpin 2, LS2, HCF2, Heparin cofactor 2, THPH10, Protease inhibitor leuserpin-2, Serpin D1 |
Target Sequences: | NM_000185 NP_000176.2 P05546 |
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