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Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Gene Name: | dehydrogenase/reductase (SDR family) member 2 |
Synonyms: | DHRS2, Dicarbonyl reductase HEP27, HEP27, Protein D, SDR25C1 |
Target Sequences: | NM_005794 NP_005785.1 Q13268 |
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