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Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Gene Name: | tumor protein p53 inducible nuclear protein 2 |
Synonyms: | TP53INP2, C20orf110, Diabetes and obesity-regulated, p53-inducible protein U, PIG-U, Diabetes and obesity regulated, DJ1181N3.1, PINH |
Target Sequences: | NM_021202 NP_067025.1 Q8IXH6 |
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