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Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Gene Name: | junctophilin 1 |
Synonyms: | JPH1, Junctophilin type 1, Mitsugumin72, Junctophilin type1, Junctophilin-1, JP-1, JP1, Junctophilin 1 |
Target Sequences: | NM_020647 NP_065698.1 Q9HDC5 |
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