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Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression.
Gene Name: | Mix paired-like homeobox |
Synonyms: | MIXL1, Homeodomain protein MIX, MIX, Mix-like homeobox protein 1, MILD1, HMix, Homeobox protein MIXL1, Mix paired-like homeobox, Mix.1 homeobox-like protein, MIXL, MIX1 homeobox-like protein 1 |
Target Sequences: | NM_031944 NP_114150.1 Q9H2W2 |
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