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CENPJ / LAP is a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.
Gene Name: | centromere protein J |
Synonyms: | CENPJ, BM032, Centromere protein J, CENP-J, LAP, LYST-interacting protein 1, LIP1, LYST-interacting protein LIP7, SASS4, Sas-4, LYST-interacting protein LIP1, CPAP, LAG-3-associated protein, MCPH6, SCKL4 |
Target Sequences: | NM_018451 NP_060921.3 Q9HC77 |
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