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Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Gene Name: | PHD finger protein 21A |
Synonyms: | PHF21A, BM-006, BHC80, BRAF35/HDAC2 complex (80 kDa), KIAA1696, PHD finger protein 21A, BHC80a |
Target Sequences: | NM_016621 NP_057705.3 Q96BD5 |
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