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KCNIP3 / Dream / Calsenilin is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene Name: | Kv channel interacting protein 3, calsenilin |
Synonyms: | KCNIP3, Calsenilin, CSEN, DREAM, DRE-antagonist modulator, KCHIP3 |
Target Sequences: | NM_013434 NP_038462.1 Q9Y2W7 |
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