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TRPC5 belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).
Gene Name: | transient receptor potential cation channel, subfamily C, member 5 |
Family/Subfamily: | Ion Channel , Calcium channel - TRP |
Synonyms: | TRPC5, CCE2, HTRP-5, HTRP5, Transient receptor protein 5, TRP5, TRP-5, Trrp5 |
Target Sequences: | NM_012471 NP_036603.1 Q9UL62 |
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