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Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Gene Name: | YY1 associated factor 2 |
Family/Subfamily: | Apoptosis |
Synonyms: | YAF2, YY1 associated factor 2, YY1-associated factor 2 |
Target Sequences: | NM_005748 NP_005739.2 Q8IY57 |
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