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Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
Gene Name: | melanoma antigen family C, 2 |
Synonyms: | MAGEC2, CT10, Cancer/testis antigen 10, HCA587, MAGE-C2 antigen, Melanoma antigen family C, 2, MAGE-E1 antigen, MAGE-C2, Melanoma-associated antigen C2 |
Target Sequences: | NM_016249 NP_057333.1 Q9UBF1 |
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