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Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Gene Name: | RBPJ interacting and tubulin associated 1 |
Synonyms: | RITA1, C12orf52, RITA |
Target Sequences: | NM_032848 CAC32398.1 Q96K30 |
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