Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
BAG4 / SODD is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Gene Name: | BCL2-associated athanogene 4 |
Family/Subfamily: | Apoptosis , Not assigned-Other |
Synonyms: | BAG4, BAG-4, Bcl-2-associated athanogene 4, BCL2-associated athanogene 4, Silencer of death domains, SODD |
Target Sequences: | NM_004874 NP_004865.1 O95429 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.