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COT / CROT is a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.
Gene Name: | carnitine O-octanoyltransferase |
Synonyms: | CROT, COT, Carnitine octanoyltransferase |
Target Sequences: | NM_021151 NP_066974.2 Q9UKG9 |
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