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Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Gene Name: | eukaryotic translation initiation factor 3, subunit L |
Synonyms: | EIF3L, EIF3S6IP, EIF3S11, EIF3EIP, HSPC021, HSPC025, MSTP005 |
Target Sequences: | NM_016091 NP_057175.1 Q9Y262 |
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