Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
PTPRO is a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
Gene Name: | protein tyrosine phosphatase, receptor type, O |
Family/Subfamily: | Protein Phosphatase , R3 |
Synonyms: | PTPRO, GLEPP1, PTP phi, PTP-U2, PTPU2, PTPase U2, R-PTP-O, NPHS6, Phosphotyrosine phosphatase U2, PTPROT, PTP-OC |
Target Sequences: | NM_002848 NP_002839.1 Q16827 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.