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DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Gene Name: | docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
Synonyms: | DOK1, Docking protein 1, Gap binding protein p62dok, p62(dok), p62DOK, Pp62 |
Target Sequences: | NM_001381 NP_001372.1 Q99704 |
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