IFI16

interferon, gamma-inducible protein 16

Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

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Antibodies (33)

Proteins (6)

ELISA Kits (5)

Type

Competitive EIA (1)

Over-Expression Lysate (2)

Primary (33)

Recombinant (4)

Sandwich (4)

Target

IFI16 (44)

Reactivity

Human (36)

Mouse (2)

Rat (3)

Application

IHC (6)

IHC-Fr (1)

IHC-P (3)

WB (33)

ELISA (7)

IF (4)

Peptide-ELISA (3)

Host

rabbit (29)

mouse (4)

Product Group

IHCPlus (2)

Isotype

IgG (13)

IgG2a,k (3)

IgG2b,k (1)

Clonality

monoclonal mc (4)

polyclonal pc (29)

Clone

1B4 (1)

2E3 (1)

4E6 (1)

5C10 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (4)

APC (1)

APC Conjugated (2)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (18)

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Epitope

aa465-671 (8)

aa386-435 (4)

700-780 aa, C-terminal (1)

Asn772 (1)

aa723-772 (1)

aa731-780 (1)

Publications

No (44)

Sample Type

Plasma (5)

Serum (5)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human IFI16 (Sandwich ELISA) ELISA Kit - LS-F32992

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$587

Select

Human IFI16 (Sandwich ELISA) ELISA Kit - LS-F27011

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

5 - 100 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

IHC-plus™ IFI16 Antibody (clone 2E3) LS-B11853

(4.0) Rating

Antibody:

IFI16 Mouse anti-Human Monoclonal (2E3) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IFI16 Antibody (clone 1B4) LS-C133267

Antibody:

IFI16 Mouse anti-Human Monoclonal (1B4) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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IFI16 Antibody LS-C331821

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

IHC-plus™ IFI16 Antibody (clone 4E6) LS-B10051

(4.0) Rating

Antibody:

IFI16 Mouse anti-Human Monoclonal (4E6) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

50 µg/$460

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IFI16 Antibody (700-780 aa, C-terminal) LS-C384051

Antibody:

IFI16 Rabbit anti-Human Polyclonal (700-780 aa, C-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

IFI16 Antibody (clone 5C10) LS-C133268

Antibody:

IFI16 Mouse anti-Human Monoclonal (5C10) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

Human IFI16 (Sandwich ELISA) ELISA Kit - LS-F18765

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

IFI16 Antibody LS-C749016

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

IFI16 Antibody LS-C805068

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

IFI16 Antibody LS-C341225

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

IFI16 Antibody LS-C413791

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$394

Select

IFI16 Antibody LS-C824128

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

IFI16 Antibody (aa723-772) LS-C292084

Antibody:

IFI16 Rabbit anti-Human Polyclonal (aa723-772) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

IFI16 Antibody (aa731-780) LS-C119992

Antibody:

IFI16 Rabbit anti-Human Polyclonal (aa731-780) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

IFI16 Antibody LS-C310691

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

IFI16 Antibody (HRP) LS-C542634

Antibody:

IFI16 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$937

Select

IFI16 Antibody (Biotin) LS-C522502

Antibody:

IFI16 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$937

Select

IFI16 Antibody (FITC) LS-C532544

Antibody:

IFI16 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$937

Select

IFI16 Antibody (APC) LS-C514287

Antibody:

IFI16 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$937

• Unconjugated
• HRP
• Biotin
• FITC
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC

Select

IFI16 Antibody LS-C658822

Antibody:

IFI16 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$386

Select

IFI16 Antibody (aa386-435) LS-C206147

Antibody:

IFI16 Rabbit anti-Human Polyclonal (aa386-435) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

IFI16 Antibody (Asn772) LS-C177840

Antibody:

IFI16 Rabbit anti-Human Polyclonal (Asn772) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

IFI16 Antibody (aa465-671) LS-C294764

Antibody:

IFI16 Rabbit anti-Human Polyclonal (aa465-671) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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